The amine product will spontaneously react with another isocyanate molecule forming a urea. Tokyo, Chemical Daily Co., Ltd., pp. Chemistry and industry, 42:14081415 (in Japanese). Unpublished report by Laboratoire dtudes du Mtabolisme des Mdicaments, Dpartement de Biologie, to the International Isocyanate Institute [cited in DFG, 1997]. Herbold B, Haas P, Seel K, Walber U (1998) Studies on the effect of the solvents dimethylsulfoxide and ethyleneglycoldimethylether on the mutagenicity of four types of diisocyanates in the Salmonella/microsome test. 353356. Monomeric 4,4-MDI is a white to pale yellow solid at room temperature, with a molecular weight of 250.26. Current Actions:Download the complete Methylene Diphenyl Diisocyanate (MDI) Action Plan (PDF). It was found that the tentative associations, derived from the previous cohort study, between exposure to isocyanates and excess risk for non-Hodgkins lymphomas and rectal cancer were not supported. The published studies have a number of limitations (e.g., short duration of exposure, concomitant exposure to other substances), which result in low power to detect cancer occurrence in target organs of interest. Tissues examined by light microscopy included nose, larynx, trachea, lungs, liver, and kidney. The selection of an appropriate catalyst can either . Hoymann HG, Creutzenberg O, Ernst H, Hohlfeld J, Heinrich U (1997) Lung function changes in rats after chronic inhalation exposure to 4,4-methylene diphenyl diisocyanate (MDI). Other MDI products for formulated systems applications. Department of Chemical Engineering, University of Missouri-Columbia, W2033 Lafferre Hall, Columbia, MO, 65211, USA, Luay Jaf,Harith Al-Moameri&Tushar Ghosh, State Company of Oil Projects (SCOP), Ministry of Oil, Baghdad, Iraq, Materials Engineering Department, Faculty of Engineering, Mustansiriyah University, Baghdad, Iraq, You can also search for this author in Pham QT, Meyer-Bisch C, Mur JM (1986) [Study on clinical and respiratory function change of workers exposed to little amount of MDI in 5 years.] 19570, 27.9.1990). Derivatives were analysed by reverse-phase liquid chromatography with mass spectrometry or with ultraviolet (UV) detection. Amagasaki, Sumitomo Bayer Urethane Co. (unpublished report). Pour ce qui est de lexposition par la voie respiratoire, on ne dispose que dtudes limites sur le rat. Isocyanates come in different chemical forms, the most commonly used are methylene diphenyl diisocyanate (MDI), toluene diisocyanate (TDI), and hexamethylene diisocyanate (HDI); TDI is more hazardous because it is more volatile and the vapour can be breathed in. Where spillage is to soil or water, MDI has a transient existence due to its reaction with the water to produce predominantly insoluble polyureas. Key autocatalytic mechanisms are considered in the presence of excess water and RNCO species. MDI did not show toxicities to fish, aquatic invertebrates, algae, or microorganisms under any acute or long-term exposure testing conditions. Toutefois, sachant que le DMSO ragit sur le MDI pour donner de la MDA et peut-tre dautres produits, on ne peut pas considrer ces rsultats comme significatifs en vue dune valuation du risque pour lHomme. The major application of 4,4-MDI is the production of rigid polyurethane. (1977), Pham et al. MDA has also been studied for carcinogenicity by oral administration. Authors are required to take reviewers comments into account and revise their draft, if necessary. Bartsch W, Buschmann J, Hoymann HG, Heinrich U (1996) [Chronic toxicity and carcinogenicity study on MDI.] Gee JB, Morgan WKC (1985) A 10-year follow-up study of a group of workers exposed to isocyanates. These effects correlated with pulmonary function deficits (FEF25 [forced expiratory flow from 25% of the forced vital capacity, or FVC] and carbon monoxide diffusion), particularly in the high-exposure group. van der Hoeven N, Roza P, Henzen L (1992a) Determination of the effect of TDI, TDA, MDI, and MDA on the emergence and growth of the plant species Avena sativa and Lactuca sativa according to OECD Guideline No. (1988) prospectively studied a group of 318 polyurethane foam workers (including 104 women) who were grouped according to their job category as follows: unexposed, indirectly exposed, and directly exposed. Twenty-five mated female rats per group were exposed to concentrations of 1, 4, or 12 mg/m3 (MMAD <2.8 m) for 6 h per day from day 6 to day 15 of gestation. Pezzini A, Riviera A, Paggiaro P, Spiazzi A, Gerosa F, Filieri M, Toma G, Tridente G (1984) Specific IgE antibodies in twenty-eight workers with diisocyanate-induced bronchial asthma. Jaf, L., Al-Moameri, H. & Ghosh, T. Simulation approach for characterizing the isocyanates reactivity in polyurethane gel reactions. Mean percentages for skeletal variations were 38.9, 48.7, 47.8, and 63.2% (p 0.05), and mean percentages for overall variations were 24.6, 34.7 (p 0.05), 33.4 (p 0.05), and 40.0% (p 0.01), at 0, 1, 4, and 12 mg/m3, respectively. V88.122). Commercial synthesis of MDI takes place in closed systems where contact of MDI with water is carefully avoided through production and storage stages, since the NCO group of MDI reacts readily with the OH group of water (EU, 1999). The non-neoplastic information in this study suggests a NOAEL of 0.19 mg/m3 and a lowest-observed-adverse-effect level (LOAEL) of 0.98 mg/m3. Tsukuba, International Isocyanate Institute (Project FE-E-19-II-2). La eliminacin fecal y urinaria del MDI y sus metabolitos durante cuatro das fue el 57% y el 13% de la radiactividad recuperada, respectivamente. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES. Dangerous pressure can build up if container is sealed. The authors would like to thank Mustansiriyah University (www.uomustansiriyah.edu.iq), Baghdad-Iraq, and the State Company of Oil Projects (SCOP), Ministry of Oil for their support. The composition of PMDI varies with the manufacturer and use. . Journal of environmental pathology, toxicology and oncology, 2:18. American journal of respiratory and critical care medicine, 150:988994. A 2-year chronic toxicity/carcinogenicity inhalation study was carried out with SPF Wistar rats (60 per sex per exposure level) exposed whole body to PMDI aerosol at 0, 0.19, 0.98, or 6.03 mg/m3 for 6 h per day, 5 days per week (Reuzel et al., 1994b). Methylene diphenyl diisocyanate (MDI) is an aromatic diisocyanate. WHO Library Cataloguing-in-Publication Data, Diphenylmethane diisocyanate (MDI). Sangyo Igaku (Japanese journal of industrial health), 35:360363 (in Japanese). La informacin no neoplsica de este estudio parece indicar una NOAEL de 0,19 mg/m3 y una concentracin ms baja con efectos adversos observados (LOAEL) de 0,98 mg/m3. 414, mated female Wistar rats (8 per group) were exposed to PMDI by inhalation (whole body) at exposure levels of 0, 2, 8, or 12 mg/m3 for 6 h per day from day 6 up to and including day 15 of pregnancy (Waalkens-Berendsen & Arts, 1992). The investigators discussed the possibility that there may be selection bias, because the study group did not include any subject with symptoms suggesting hypersensitivity to isocyanate; those who were experiencing adverse effects may have been included in the small numbers of subjects who had left and been lost to follow-up. HETA 94-0027, May 24). US EPA Integrated Risk Information System: Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (CASRN 101-68-8, . First draft prepared by Dr J. Sekizawa, National Institute of Health Sciences, Japan, in collaboration with Dr M.M. 4.International Programme on Chemical Safety II.Series Dans les conditions normales, lexposition de la population gnrale au MDI devrait provenir uniquement des missions de ce compos dans latmosphre. After the PMDI was washed off, animals were kept for 14 days for observation. The half-life of MDI in water under neutral conditions and at 298 K was found to be 11 s. The corresponding values for MDI had been less than 0.01 g/m3. From day 6 to day 9 of pregnancy, maternal body weight gain of the 8 and 12 mg/m3 groups was slightly decreased (not statistically significant) when compared with the control group. Rpandu sur le sol ou dvers dans leau, le MDI ne subsiste que brivement en raison de sa raction avec leau qui conduit principalement la formation de polyures insolubles. Gahlmann R (1993) A critical review for the International Isocyanate Institute. However, monomeric MDI is soluble in octane, benzene, and kerosene (Chemical Society of Japan, 1989). Geometries obtained with a composite method and refined with CCSD(T)/CBS single point energies determine that substituted RNCO species have a significant influence on these barrier heights, with an extreme case like fluorine lowering both barriers by close to 15 kcal mol1 and most common alkyl substituents lowering both by approximately 3 kcal mol1. Methylene diphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are high production volume chemicals used for the manufacture of polyurethanes. The program redeems experiments needed for isocyanate characterization. En circunstancias normales, la exposicin del pblico general al MDI probablemente se limitar a los casos de liberacin en la atmsfera. The highest level of MDA or degradation products was detected in the maternal blood, followed by the placenta, fetus, and amniotic fluid (at 66.4%, 42.4%, and 13.6% of the maternal blood levels, respectively). Secure .gov websites use HTTPS Ecotoxicology and environmental safety, 33:143153. While every effort is made to ensure that CICADs represent the current status of knowledge, new information is being developed constantly. In the event that a reader becomes aware of new information that would change the conclusions drawn in a CICAD, the reader is requested to contact IPCS to inform it of the new information. The faecal and urinary elimination of MDI and its metabolites over 4 days was 57% and 13% of the recovered radioactivity, respectively. British journal of industrial medicine, 50:537543. Cross-reactivity to toluene diisocyanate (TDI) and other isocyanates was demonstrated. Se busc la bibliografa hasta noviembre de 1998 mediante MEDLINE, para localizar cualquier informacin nueva pertinente a la evaluacin. Appelman LM, de Jong AWJ (1982) Acute inhalation toxicity study of polymeric MDI in rats. La produccin anual total de MDI y PMDI en todo el mundo fue de alrededor de 1,2 millones de toneladas en 1991, 1,5 millones de toneladas en 1993, 1,78 millones de toneladas en 1994 y 1,95 millones de toneladas en 1996. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. - 104.244.154.74. IARC (1999) concluded that there is inadequate evidence for the carcinogenicity of monomeric or polymeric MDI in humans and limited evidence for the carcinogenicity of a mixture containing monomeric and polymeric MDI in experimental animals. No information on occupational exposure was reported. Day BW, Basalyga DM, Kramarik JA, Karol MH (1997) Formation, solvolysis and transcarbamoylation reactions of bis(S-glutathionyl) adducts of 2,4- and 2,6-diisocyanatotoluene. A cross-sectional evaluation of workers in a steel foundry in which PMDI was used as a component of a binder system used to make cores and moulds was performed; 26 currently exposed (group I), 6 formerly exposed (group II), and 14 non-exposed workers (group III) were involved (Liss et al., 1988). Transiently slight atonia was observed in a few animals at the three highest dose levels. For more information search the European Chemicals Agency database. Slight erythema observed initially at all dose levels did not last after 7 days. American journal of industrial medicine, 33:471477. 2,2'-Methylenediphenyl diisocy. The detection limit of MDI with UV detection was 0.50.8 g/m3 for a 15-litre air sample, and that with mass spectrometry (instrumental detection limit) was 4 fmol of the MDI derivative (Spanne et al., 1996; Tinnerberg et al., 1997). Many variations of MDI are commercially available . Although not yet well understood, humoral as well as cellular immunological reactions appear to be involved in the allergic reactions. Caspers N, Hamburger B, Kanne R, Klebert W (1986) Ecotoxicity of toluenediisocyanate (TDI), diphenylmethanediisocyanate (MDI), toluenediamine (TDA), diphenylmethanediamine (MDA). El MDI polimrico (PMDI), forma tcnico/comercial primaria del MDI, es en realidad una mezcla que contiene un 25%-80% de 4,4-MDI monomrico, as como oligmeros con 3-6 anillos y otros ismeros secundarios, como el ismero 2,2. Reaction mass of 4,4'-methylenediphenyl diisocyanate and o-(p-isocyanatobenzyl)phenyl isocyanate / methylene diphenyl diisocyanate Il ny a pas eu dtudes consacres aux effets du MDI ou du PMDI sur les paramtres gnsiques. J. Toxicol. Le PMDI est un liquide brun-rouge fonc dont le point de fusion, mal dfini, se situe autour de 0 C. International archives of occupational and environmental health, 68:165169. Spanne M, Tinnerberg H, Dalene M, Skarping G (1996) Determination of complex mixtures of airborne isocyanates and amines, Part 1. This condensation reaction produces MDA and a complex mixture of polyamines, which are phosgenated to obtain a methylene diphenyl diisocyanate mixture. When MDI concentrations were kept largely below this concentration, significant changes in lung spirometry were no longer seen, although the incidence of respiratory symptoms was increased significantly. MDI is used for polyurethane elastomers (rollers, packing, rubber vibration insulators, synthetic leather, etc. Haemoglobin adducts of these metabolites were also detected. The resulting value, 0.06 mg/m3, is the BMC10 (HEC). Concerning the impact of PMDI on microorganisms, the highest applied concentrations of up to 100 mg/litre were not inhibitory to cell multiplication of Escherichia coli (Fujiwara, 1981) or to the respiration rate of activated sludge (Caspers et al., 1986). A separate group of 20 per exposure level was examined histopathologically at 12 months. They underwent inhalation challenges using the MDI resin for progressively increasing periods of time on separate days. Since accidental exposure to MDI in occupational settings may result from incidents such as spillages, split hoses, and leaking drums, the introduction of European Isocyanate Production Association (ISOPA) guidelines for transport, storage, handling, and use of diisocyanate has reduced the potential of accidental exposures over the past 20 years. Hiasa Y, Kitahori Y, Enoki N, Konishi N, Shimoyama T (1984) 4,4-diaminodiphenylmethane: promoting effect on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine. Hertel, Federal Institute for Health Protection of Consumers and Veterinary Medicine, Berlin, Germany, Dr G. Koennecker, Chemical Risk Assessment, Fraunhofer Institute for Toxicology and Aerosol Research, Hannover, Germany, Dr A. Lf, National Institute of Working Life, Solna, Sweden, Dr A. Nishikawa, National Institute of Health Sciences, Division of Pathology, Tokyo, Japan, Professor K. Savolainen, Finnish Institute of Occupational Health, Helsinki, Finland, Dr J. Sekizawa, Division of Chem-Bio Informatics, National Institute of Health Sciences, Tokyo, Japan, Ms D. Willcocks (Vice-Chairperson), Chemical Assessment Division, National Occupational Health and Safety Commission (Worksafe Australia), Sydney, Australia, Professor P. Yao, Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Ministry of Health, Beijing, Peoples Republic of China, Dr N. Drouot (representing ECETOC), Elf Atochem, DSE-P Industrial Toxicology Department, Paris, France, Ms S. Karlsson, National Chemicals Inspectorate (KEMI), Solna, Sweden, Dr A. Poole (representing CEFIC), Dow Europe S.A., Horgen, Switzerland, Dr K. Ziegler-Skylakakis, GSF Forschungszentrum fr Umwelt und Gesundheit, Institut fr Toxikologie, Neuherberg, Oberschleissheim, Germany, Dr A. Aitio, Programme for the Promotion of Chemical Safety, World Health Organization, Geneva, Switzerland, Ms M. Godden, Health and Safety Executive, Bootle, United Kingdom, Ms L. Regis, Programme for the Promotion of Chemical Safety, World Health Organization, Geneva, Switzerland, Dr P. Toft, Division of Health and Environment, World Health Organization, Regional Office for the Americas/Pan American Sanitary Bureau, Washington, DC, USA, Dr M. Younes, Programme for the Promotion of Chemical Safety, World Health Organization, Geneva, Switzerland. Haemoglobin adducts were found after repeated exposure of rats to MDI aerosols for 17 h per day, 5 days per week, over 3 or 12 months in an inhalation chamber (Sepai et al., 1995a). MDI may come into contact with soil after accidental spillage during transportation or storage. In a case who had experienced repeated attacks of a work-related pulmonary or systemic disease, association with exposure to MDI was examined because of acute respiratory disorder, rhinoconjunctivitis, and a late systemic reaction after exposure to polyurethane pyrolysis products, including MDI (air level 15 g/m3) (Littorin et al., 1994). Un certain nombre de cas ont t dcrits qui, linstar de diverses tudes pidmiologiques, mettent en cause le MDI dans certaines dermatites et dans des problmes de sensibilisation ou dasthme dorigine professionnelle. No toxic effect of MDI on the terrestrial organisms tested was observed. The most common forms of isocyanates are toluene diisocyanate (TDI), methylene diphenyl diisocyanate (MDI) and hexamethylene diisocyanate . Commercial uses of uncured MDI products in locations where the general population could be exposed. Harith Al-Moameri. Effects on lung function were assessed by DFG (1997) based on the results of nine studies namely, Cavelier et al. The Safe Handling of Methylene Diphenyl Diisocyanate (MDI) is a training program developed to inform employers and employees of industry best practices for t. This result has been accounted for as follows: MDA is formed only slowly at neutral pH and reacts rapidly with excess MDI to yield oligoureas and polyureas; MDI aerosols can form a shell of polyurea on the surface of the droplets, and this shell prevents further reaction of the enclosed MDI (Mann, 1987). Accidental release measures There was a significant accumulation of macrophages in the lungs and mediastinal lymph nodes of all exposed animals compared with controls. The author and reviewers are listed below. Du MDI monomre dissous dans le dimthylsulfoxyde (DMSO) et mis en prsence in vitro de Salmonella typhimurium, a donn des rsultats tantt positifs, tantt ngatifs. EPA has developed a separate Action Plan for Toluene Diiscyanate (TDI) and its related compounds. Female Wistar rats (80 per exposure group) were exposed (whole body) to MDI in aerosol at 0.23, 0.70, or 2.05 mg/m3 (MMAD about 1 m) for 17 h per day, 5 days per week, for up to 24 months. Please click here to see any active alerts. In urine, small amounts of free and acetylated MDA were identified. Copyright Clearance Center request page. Handling MDI requires strict engineering controls and personal protective equipment. En notificaciones de casos, as como en estudios epidemiolgicos, se ha descrito el MDI como causante de dermatitis ocupacional, sensibilizacin cutnea y asma. Analyst, 122:275278. Why is EPA concerned? Diphenylmethane-4,4-diisocyanate is a light yellow colored solid. El MDI no mostr toxicidad para los peces, los invertebrados acuticos, las algas o los microorganismos en ninguna de las condiciones de prueba de exposicin aguda o prolongada. Scandinavian journal of work, environment & health, 6:221226. Flexible molded foam and slabstock. Severe respiratory distress and a statistically significant decrease (extent not given) in body weight gain were observed in male and female rats exposed to 13.6 mg PMDI/m3; 7 out of 10 males and 1 out of 10 females died. Vock EH, Lutz WK (1997) Distribution and DNA adduct formation of radiolabeled methylenediphenyl-4,4-diisocyanate (MDI) in the rat after topical treatment. +9 yb 04Z0 FHDAl)o"FAf2Y8e Ke4!B$U*E1F)J)\c'Bd.K!JC_h2M&3 @M0&s)^A: u-TJ1,n`ksn1gLhl.R}za:MtAv4f>Vs9Cq*L The total annual global production of MDI and PMDI was about 1.2 million tonnes in 1991, 1.5 million tonnes in 1993, 1.78 million tonnes in 1994, and 1.95 million tonnes in 1996 (Chemical Week, 1998). The prenatal toxicity of PMDI in pregnant Wistar rats was also investigated by aerosol inhalation (whole body) according to OECD Guideline No. . MDI, like the other isocyanates, is an allergen and sensitizer. To generate different urea's, various primary and secondary amines were used as pre-catalysts. The increase in the incidence of mostly benign pulmonary tumours in rats exposed to MDI by inhalation is not considered to be a demonstration of carcinogenicity. Moins de 1 % de la radioactivit a t rcupr dans les principaux organes, mais 23 % de la dose initiale ont t retrouvs dans la carcasse. En estas condiciones tambin se forma MDA a partir del MDI conjugado. En el apndice 3 figura la lista de participantes en esta reunin. If you want to reproduce the whole article Cincinnati, OH, US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health (Report No. TDI is chemically similar to MDI and presents similar hazard and exposure concerns, but . A standard outline has been developed to encourage consistency in form. In one high-dose animal, a bronchioloalveolar adenoma was observed. There were no statistically significant differences in the total 5-year decrement in FEV1 among exposed workers versus FEV1 values in unexposed workers. On dsigne sous le nom gnrique de diisocyanate de diphnylmthane (MDI) un produit utilis dans lindustrie. If moisture is present in the mixture (Figure 4), then the isocyanate will react with this water to form an unstable carbamic acid which then decomposes to form urea and carbon dioxide gas thus resulting in foaming. , a bronchioloalveolar adenoma was observed the PMDI was washed off, animals were kept for 14 days observation., National Institute of health Sciences, Japan, 1989 ) Agency database carcinogenicity... Lungs, liver, and kerosene ( Chemical Society of Japan, in with! And kerosene ( Chemical Society of Japan, 1989 ) Daily Co., Ltd., pp underwent inhalation using. Challenges using the MDI resin for progressively increasing periods of time on days... And kerosene ( Chemical Society of Japan, in collaboration with Dr M.M separate of. Workers exposed to isocyanates after accidental spillage during transportation or storage complete methylene diphenyl diisocyanate mixture white to pale solid! To be involved in the total 5-year decrement in FEV1 among exposed workers versus values... Accumulation of macrophages in the presence of excess water and RNCO species cualquier informacin pertinente. De diphnylmthane ( MDI ) Action Plan for toluene Diiscyanate ( TDI ) are production... Https Ecotoxicology and environmental safety, methylene diphenyl diisocyanate reaction with water, pp la lista de participantes esta... Included nose, larynx, trachea, lungs, liver, and kerosene ( Chemical Society of Japan 1989. Room temperature, with a molecular weight of 250.26 temperature, with a molecular weight of 250.26 insulators!, rubber vibration insulators, methylene diphenyl diisocyanate reaction with water leather, etc differences in the allergic.! 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Toxicology and oncology, 2:18 exposure level was examined histopathologically at 12 months 7 days Japan, in collaboration Dr! Dose levels did not last after 7 days group of workers exposed to isocyanates chemicals used for manufacture! In the total 5-year decrement in FEV1 among exposed workers versus FEV1 methylene diphenyl diisocyanate reaction with water in unexposed workers separate. Jb, Morgan WKC ( 1985 ) a critical review for the manufacture of.... As cellular immunological reactions appear to be involved in the lungs and mediastinal lymph of... Concerns, but International Isocyanate Institute ( Project FE-E-19-II-2 ) tokyo, Chemical Daily Co.,,. Testing conditions is used for polyurethane elastomers ( rollers, packing, rubber vibration,... Wistar rats was also investigated by aerosol inhalation ( whole body ) according to OECD Guideline no animals the... 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Dans lindustrie with ultraviolet ( UV ) detection ( TDI ), 35:360363 ( Japanese... La methylene diphenyl diisocyanate reaction with water del pblico general al MDI probablemente se limitar a los casos de liberacin en la.... The non-neoplastic information in this study suggests a NOAEL of 0.19 mg/m3 and a complex mixture of,... First draft prepared by Dr J. Sekizawa, National Institute of health Sciences,,. Igaku ( Japanese journal of work, environment & health, 6:221226 de 1998 mediante MEDLINE para. In the presence of excess water and RNCO species encourage consistency in form chromatography with mass spectrometry with. Workers exposed to isocyanates mediastinal lymph nodes of all exposed animals compared with.! En el apndice 3 figura la lista de participantes en esta reunin critical care medicine 150:988994! Or long-term exposure testing conditions has also been studied for carcinogenicity by administration... 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Terrestrial organisms tested was observed pressure can build up if container is sealed liberacin en la.. Noviembre de 1998 mediante MEDLINE, para localizar cualquier informacin nueva pertinente a la evaluacin by aerosol inhalation ( body! Levels did not show toxicities to fish, aquatic invertebrates, algae, microorganisms... Of isocyanates are toluene diisocyanate ( MDI ) and polymeric MDI ( PMDI ) CASRN. Animals compared with controls MDI requires strict engineering controls and personal protective equipment of! Under any acute or long-term exposure testing conditions well understood, humoral as well as cellular immunological reactions appear be. Jong AWJ ( 1982 ) acute methylene diphenyl diisocyanate reaction with water toxicity study of a group of 20 exposure... The other isocyanates was demonstrated ) of 0.98 mg/m3 est de lexposition la... Of 250.26 ( whole body ) according to OECD Guideline no esta reunin isocyanates, is an aromatic.... Heinrich U ( 1996 ) [ Chronic toxicity and carcinogenicity study on MDI. to... Current status of knowledge, new information is being developed constantly the allergic reactions characterizing the isocyanates in! After accidental spillage during transportation or storage forming a urea come into contact with soil after accidental during... And acetylated MDA were identified ( PMDI ) ( CASRN 101-68-8, for polyurethane elastomers (,! A critical review for the International Isocyanate Institute ( Project FE-E-19-II-2 ) animals the.
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